Fig. 8

Gait pattern of MBP29-hα-syn mice (MBP29). a Graphical overview illustrating gait parameters measured by the Catwalk XT gait analysis system including the print position, base of support (BOS) of fore (FP) and hind paws (HP), stride length, as well as swing and stance time. Abbreviations: Right fore paw (RF), right hind paw (RH), left fore paw (LF), and left hind paw (LH). b–j Ataxic gait in MBP29-hα-syn (n = 24) compared to non-transgenic (ntg) mice (n = 24) at 8, 12, and 16 weeks of age. Parameters include average speed (b), BOS of fore (c), and hind paws (d), print position (e), stride length of fore (f) and hind paws (g) normalized (norm.) to the mean bodyweight at each time point, as well as the proportion of dual diagonal (h), dual lateral (i), and three paw support (j). Paws highlighted in yellow illustrate the respective paw position i.e. dual diagonal (h), dual lateral (i), and three paw support (j). Data represent mean ± standard error of the mean. Statistical analyses were performed using Mann–Whitney test for comparison of MBP29-hα-syn and ntg mice at each time point, Wilcoxon signed-rank test for comparison of 8- and 16-week-old MBP29-hα-syn mice; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001