Fig. 6

Increased number of IBA1⁺ microglia in cerebellar white matter in MBP29-hα-syn (MBP29) mice at 8 and 16 weeks of age. a Graphical overview illustrating regions of interest within the mouse cerebellum including the cerebellar white matter (cbw) and cortex (cbx)  according to [35] ; coordinates: Interaural: -2.00 mm, Bregma: -5.79 mm. b The number of IBA1⁺ cells as marker for myeloid cells is significantly increased in the cbw in 8- and 16-week old MBP29-hα-syn (n = 6) compared to non-transgenic (ntg) mice (n = 6). Note the contrast of microgliosis in cbw and cbx. Scale bar: 50 µm. Data represent mean + standard deviation. Statistical analyses were performed using Mann–Whitney test; **p ≤ 0.01