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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy

Fig. 5

Increased number of OLIG2+ oligodendrocytes in 8- and 16-week-old MBP29-hα-syn (MBP29) mice. a Graphical overview illustrating regions of interest within the mouse cerebellum including the cerebellar white matter (cbw) and cortex (cbx)  according to  [35]; coordinates: Interaural: -2.00 mm, Bregma: -5.79 mm. b Maximum intensity projection images showing OLIG2 (red) as oligodendrocyte-specific marker and PDGFRα (white) as marker for oligodendrocyte precursor cells within the cbw; DAPI+ nuclei are shown in blue; scale bar: 50 µm. c, d The number of OLIG2+ cells is increased in the cbw, but not in the cbx in 8- (c) and 16-week-old (d) MBP29-hα-syn mice (n = 6) compared to non-transgenic (ntg) mice (n = 6). The ratio of oligodendrocyte precursor cells to total oligodendrocyte number are expressed as proportion of PDGFRα to OLIG2 given in percentage. Note the proportional decrease of PDGFRα + oligodendrocyte precursor cells in MBP29-hα-syn mice at 8 and 16 weeks of age. Data represent mean + standard deviation. Statistical analyses were performed using Mann–Whitney test; *p ≤ 0.05, **p ≤ 0.01

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