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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy

Fig. 1

Experimental paradigm. For longitudinal gait analysis, 24 MBP29-hα-syn (MBP29) mice that completed gait analysis were compared to 24 control mice (ntg). For the subgroup gait analysis at an age of 8 weeks, 24 MBP29-hα-syn mice were compared to 12 MBP29-hα-syn mice that were not able to be assessed completely. Following gait analysis, the 16-week-old mice and an additional cohort of 8-week-old mice (n = 18 MBP29, n = 20 ntg) were transcardially perfused and cerebellar tissue was used for histological, mRNA (quantitative real-time PCR, qPCR), and protein analysis (Western Blot, WB)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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