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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery

Fig. 5

Brain volumetric analysis using T2WI in mice with and without spontaneous seizures. a T2WI showing brain coronal sections 3 months post-TBI in representative PTE (left) and No-SRS (right) mice. The white area corresponds to the lesion area. b Bargrams showing the longitudinal quantification of the lesion volume using T2WI images 3 weeks and 3 months post-TBI (PTE, n = 6; No-SRS, n = 5). Data are the mean ± SEM and the single values. c T2WI depicting representative brain coronal sections of a control mouse showing the ROIs used to quantify the volumes of selected brain regions, i.e. cortex (green), hippocampus (yellow), thalamus (blue), and striatum (pink). dg Bargrams showing the volumetric analysis at 3 weeks and 3 months post-TBI (controls, n = 8; PTE, n = 6; No-SRS, n = 5). The mean and SEM of control animals are shown by continuous and dotted black lines, respectively. Statistical analyses were done using the corresponding contralateral values. Data are the mean ± SEM and the single values. *p < 0.05, **p < 0.01 versus corresponding contralateral control by Kruskall-Wallis

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