Table 1 Dual IHC with CD68 and TNFα or TNFα and VCAM1 on pretreated human IDH-wt GBM sections
Pathology | Avastin (A) or Untreated (U) | CD68 positive cells | TNFa positive cells | % of double positive cells | Tissue area (μm2) | CD68 positive/mm2 | % TNFa Positive Cells/CD68 positive/mm2 | VCAM1 | Survival from start of Avastin (days) |
|---|---|---|---|---|---|---|---|---|---|
S10-10131 | U | 11,724 | 10,305 | 87.896622 | 50,922,572 | 230.2318901 | 0.381774314 | High | |
S10-1813 | U | 10,403 | 297 | 2.854946 | 86,029,352 | 120.9238447 | 0.023609454 | Low | |
S10-18509 | U | 13,843 | 11,179 | 80.755615 | 221,351,008 | 62.53868065 | 1.291290673 | High | |
S10-18918 | U | 7416 | 1082 | 14.590075 | 184,785,120 | 40.13310163 | 0.363542174 | Med | |
S10-20729 | U | 1723 | 818 | 47.475334 | 223,205,936 | 7.719328755 | 6.150189415 | High | |
S10-23850 | U | 4105 | 4034 | 98.270401 | 65,117,496 | 63.0398933 | 1.558860522 | High | |
S10-24725 | U | 2858 | 2793 | 97.725685 | 16,088,890 | 177.6381093 | 0.550139187 | High | |
S10-25121 | U | 1657 | 19 | 1.146651 | 121,491,016 | 13.63886857 | 0.084072296 | low | |
S10-25659 | U | 11,966 | 6770 | 56.576969 | 18,454,342 | 648.4110894 | 0.087254783 | Low | |
S10-2928 | U | 7170 | 4231 | 59.009762 | 62,469,184 | 114.7765913 | 0.514127152 | Med | |
S10-31365 | U | 8253 | 4636 | 56.173512 | 71,736,504 | 115.0460301 | 0.488269886 | low | |
S10-32073 | U | 17,689 | 6975 | 39.431286 | 125,374,008 | 141.0898501 | 0.279476418 | low | |
S10-32286 | U | 19,867 | 6373 | 32.07832 | 71,390,272 | 278.2872154 | 0.115270549 | Med | |
S10-33315 | U | 1131 | 398 | 35.190098 | 228,310,704 | 4.953775623 | 7.10369235 | High | |
S10-33655 | U | 3338 | 852 | 25.524265 | 181,316,576 | 18.40978952 | 1.386450669 | High | |
S10-36172 | U | 2921 | 2837 | 97.124275 | 13,749,701 | 212.4409833 | 0.457182383 | High | |
S10-37332 | U | 5289 | 3948 | 74.645493 | 72,317,608 | 73.13571544 | 1.020643506 | High | |
S10-37372 | U | 8600 | 5705 | 66.337212 | 88,101,760 | 97.61439499 | 0.679584318 | Med | |
S10-37487 | U | 5529 | 3230 | 58.419243 | 82,281,136 | 67.19644707 | 0.869379938 | Med | |
S10-38393 | U | 26,935 | 13,018 | 48.331169 | 81,640,520 | 329.9219554 | 0.146492733 | Med | |
S10-41235 | U | 18,022 | 10,180 | 56.486515 | 105,453,928 | 170.8992765 | 0.330525185 | Med | |
S10-5238 | U | 19,134 | 4786 | 25.013065 | 147,458,384 | 129.7586443 | 0.192766078 | Low | |
S10-6120 | U | 14,592 | 14,338 | 98.259323 | 14,052,854 | 1038.365588 | 0.094628832 | Low | |
S10-6519 | U | 1670 | 1644 | 98.443115 | 3,186,010.75 | 524.1664674 | 0.187808876 | Low | |
S10-8682 | U | 346 | 45 | 13.00578 | 242,124,560 | 1.429016536 | 9.101210289 | High | |
S10-27805 | A | 8556 | 4975 | 58.146332 | 209,370,352 | 40.8653848 | 1.422874941 | Med | 334 |
S09-12484 | A | 7436 | 0 | 0 | 101,027,248 | 73.60390535 | 0 | Low | 708 |
S11-33469 | A | 32,588 | 4493 | 13.787284 | 138,144,512 | 235.897898 | 0.058445981 | Low | 497 |
S11-37524 | A | 12,304 | 6065 | 49.292912 | 70,076,544 | 175.579435 | 0.280744223 | High | 85 |
S11-37558 | A | 36,049 | 1530 | 4.244223 | 300,741,824 | 119.8669328 | 0.035407788 | Low | 289 |
S12-13992 | A | 10,632 | 825 | 7.759593 | 206,245,344 | 51.55025463 | 0.150524824 | Low | 295 |
S12-44046 | A | 1867 | 509 | 27.262989 | 129,823,864 | 14.3810232 | 1.895761423 | High | 194 |
S12-49013 | A | 3578 | 840 | 23.476803 | 253,127,344 | 14.13517775 | 1.660877806 | High | 116 |
S12-55823 | A | 20,895 | 15,731 | 75.285957 | 65,120,496 | 320.8667207 | 0.234633111 | Med | |
S12-65416 | A | 14,518 | 6556 | 45.157734 | 59,637,560 | 243.4371896 | 0.185500556 | Low | 409 |
S12-78023 | A | 986 | 0 | 0 | 292,213,728 | 3.374242568 | 0 | Low | 97 |
S13-23668 | A | 8512 | 2619 | 30.768328 | 88,663,336 | 96.00360627 | 0.320491377 | Med | 152 |
S13-27592 | A | 708 | 482 | 68.079094 | 36,016,252 | 19.65779227 | 3.46321159 | High | 80 |
S14-35506 | A | 5734 | 4572 | 79.734917 | 57,075,904 | 100.4627101 | 0.793676747 | High | 69 |
Average | 10,013.94872 | 4351.025641 | 47.53233069 | 117,581,891 | 158.7550979 | 1.127189547 |