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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes

Fig. 9

Long-term metabolomic abnormalities after rmTBI. a Confusion matrix using a random forest classifier demonstrates the accuracy with which metabolomics can be used to classify mice as either control, 48 h, 1 week, 4 w or 10 w post-rmTBI. The greatest accuracy was achieved for metabolomic profiles from animals 10 post-rmTBI (89%). A Mann–Whitney U Test was performed looking for statistically significant differences between every pair of time points for each metabolite. A Bonferroni correction was then used to correct the family-wise error rate. After the correction, there were 32 points of statistical significance spread across 26 metabolites. b A heat map displaying the levels of these metabolites relative to control levels (black) are shown. Almost all of the metabolites (23/26) are phosphatidylcholines or lyso-phosphatidylcholines and show similar patterns of expression: low (blue hues) early after rm-TBI and significantly higher (reddish hues) at 10 w after rmTBI

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