Fig. 7

Morris Water maze deficits in rm-TBI mice. At 16-week post rmTBI, all the mice were trained for 4 consecutive days (4 sessions per day; platform in Quadrant 4) and performed probe test on day 5. a There was no difference between shams and rmTBI mice in escape latency during the training phase of the test (2-way ANOVA for A (F(3,108) = 1.127, p = 0.34). b Sham but not rmTBI mice spent more time in the target quadrant (Q4) compared to the average time spent in the non-target quadrants (Q1–3) during the probe trial (One-way ANOVA for b (F(3,48) = 29.13, p < 0.001). The time that a mouse might spend in any one quadrant by chance (15 s out of the 60 allotted for the trial) is shown by the dashed line. c Representative movement traced at day 1 training and probe trial from sham mouse and rmTBI mouse; red dot indicated the location of the hidden platform (in Q4); black star indicated the location where the mouse was released into to the pool (in Q2). d RmTBI mice traveled a greater distance than sham mice until their first entry into the target quadrant during the probe trial (Student t-test). Asterisk denotes statistically significant difference compared to shams p < 0.05