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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes

Fig. 4

Repetitive mTBI leads to a mild inflammatory response. Western blot and subsequent densitometric analyses show time-course of GFAP (a), Iba1 (b), TNFα (c) and IL-6 (d) levels in the prefrontal cortex from mice 48 h after the last sham procedure and from mice 8 h, 48 h and 1 week post-injury. β-actin levels were used as a loading control. (Asterisk indicates statistically different from shams, and # indicates statistically different from rmTBI 48 h, p < 0.05; one-way ANOVA). Representative immuno-fluorescent stained photomicrographs showing GFAP and Iba1 expression in the corpus callosum in controls (e), and in mice at 48 h (f), 1 week (g) and 10 w (h) post-rmTBI. Scale bar = 50 μm. Higher magnification images of Iba1 immunostaining to better demonstrate microglial morphology at the corresponding time points are shown in the insets (e′–h′). Scale bar in e’–h’ = 20 μm

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