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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

Fig. 8

FKBP52 induces gliosis in hippocampal adjacent cortices without affecting total tau expression. Analysis of cortical subregions from 16-month-old wild-type mice expressing AAV9-mCherry, AAV9-Aha1, or AAV9-FKBP52 stained for (a) tau, (b) AT8 (pS202/T205), (c) astrocyte marker (GFAP), and (d) microglial marker (IBA1). N = 6/AAV. Relative intensity was analyzed by one-way ANOVA followed by Tukey post-hoc test for each subregion. Statistical significance is indicated by *p < 0.05 and **p < 0.01. Results represented as standard error of the mean (± SEM). TeA/Ect, temporal association cortex and ectorhinal cortex; Pir, perirhinal cortex; Ent, entorhinal cortex; Sub, subiculum

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