Fig. 2
From: Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
FKBP52 impairs spatial reversal learning, while Aha1 impairs associative learning. AAV9-mCherry, AAV9-Aha1, and AAV9-FKBP52 injected wild-type mice were tested using the open field for (a) locomotor activity—indicated by total distanced traveled- and (b) anxiety-like behavior—indicated by total time spent in the center. (c) Percent time freezing was measured in fear conditioning—a behavioral task of associative learning and memory. (d) Spatial learning and memory using the radial-arm water maze (RAWM) test: Day 1-Training, Day 2-Testing, and Day 3-Reversal Testing. N = 6/AAV. Open field was analyzed by a one-way ANOVA while fear conditioning and RAWM by repeated measures two-way ANOVA. This was followed by Tukey post-hoc test when group significance was found. Results represented as standard error of the mean (± SEM). #p = 0.07, *p < 0.05, **p < 0.01. m, meters; s, s