Fig. 1
From: Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
AAV9 injection timeline and expression validation. (a) Timeline of bilateral hippocampal injections with AAV9-mCherry (control), AAV9-Aha1, or AAV9-FKBP52. At 15.5 months of age, mice were exposed to cognitive behavioral testing followed by brain collection for immunohistochemistry analysis. N = 6/AAV. (b) Representative images and quantification of viral expression after 7 months of injection in hippocampal sections from wild-type mice. Relative intensity was analyzed by Student’s unpaired t-test comparing outside (control) and inside areas of injection. Statistical significance is indicated by **p < 0.01. Results are represented as standard error of the mean (± SEM). Scale bar represents 100 µm; inset scale represents 10 µm. AAV9, adeno-associated virus serotype 9