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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice

Fig. 9

Aged male GrnR493X/R493X mice exhibit an increased anxiety phenotype. Proportion of time male/female (a), male (b), and female (c) Grn+/+ and GrnR493X/R493X mice spent inside the center region of an open-field arena over a 10 min trial. Male Grn+/+ n = 12, female Grn+/+ n = 15, male GrnR493X/R493X n = 10, and female GrnR493X/R493X n = 10; values are shown as mean ± SEM; ns = not significant, *p < 0.05, Student’s t-test

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