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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice

Fig. 8

Neurodegeneration of thalamic Foxp2 + excitatory neurons in aged GrnR493X/R493X mice. a Representative hippocampal/thalamic tilescans from 18 month old Grn+/+ and GrnR493X/R493X mice brain sections stained for Foxp2, the dashed outline depicts area quantified in (b) (scale bar, 500 µm). b Quantification of total number of thalamic Foxp2-positive nuclei. n = 9 male Grn+/+ mice, n = 7 female Grn+/+ mice, n = 7 male GrnR493X/R493X, and n = 10 female GrnR493X/R493X mice were used; values are shown as mean ± SEM; ***p < 0.0001, Student’s t-test

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