Fig. 3
From: Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability
Vascular deposition in the brain of APP/PS1 mice challenged with AD brain extracts. a–f Double immunofluorescence staining for Aβ (green) and SMA (red) in mice’s brains inoculated with human AD brain extracts. g The extent of amyloid deposition associated with vessels was calculated as previously reported [45] using bright field images. Values for each group are expressed as the area of Aβ 4G8-inmunoreactivity in vascular structures divided by the total Aβ burden and multiplied by 100. N = 4–6/group. Data value were expressed as mean ± SEM. Data were analyzed by one-way ANOVA followed by Tukey's multiple comparison post-test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001