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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability

Fig. 2

Aβ seeding activity of pathologically diverse AD brains. Brain cortex (af) and hippocampus (gl) of mice inoculated with different brain extracts were analyzed for their content of Aβ deposits. Equivalent specimens from untreated mice were included as controls. m, n Image analysis quantification (% burden) of Aβ pathology in cortex (m) and hippocampus (n). o The intrinsic seeding capacity of each inoculum was calculated as the ratio between Aβ burden in each mouse and the burden in the inoculum used for treatment. N = 4–6/group. Data value were expressed as mean ± SEM. Data from M and N were analyzed by Student's t-test comparing the experimental groups with Aged Brain. Data from o were analyzed by one-way ANOVA followed by Tukey's multiple comparison post-test. *p < 0.05, **p < 0.01, ***p < 0.001

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