Table 5 Top GSA-SNP2 pathway associations in the GWAS of resilience to amyloidosis
Pathway [Database] | Number of genes | p value | Function |
|---|---|---|---|
Integrin-2 pathway [PID] | 26 | 4.17 × 10–6 | Cell adhesion |
Negative regulation of TCF-dependent signaling by WNT ligand antagonists [Reactome] | 15 | 2.24 × 10–5 | Immune response; signal transduction |
FCGR activation [Reactome] | 11 | 7.14 × 10–5 | Immune response |
Keratinization [Reactome] | 171 | 1.94 × 10–4 | Cell adhesion |
Adipogenesis [WikiPathways] | 119 | 2.23 × 10–4 | Lipid metabolism |
Photodynamic therapy-induced unfolded protein response [WikiPathways] | 26 | 5.94 × 10–4 | Cellular stress response |
SNARE interactions in vesicular transport [KEGG] | 35 | 8.63 × 10–4 | Neurotransmitter release |
Formation of the cornified envelope [Reactome] | 118 | 8.98 × 10–4 | Keratinocyte cell barrier |
Interferon gamma pathway [ST] | 10 | 0.001 | Immune response |