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Table 5 Top GSA-SNP2 pathway associations in the GWAS of resilience to amyloidosis

From: Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

Pathway [Database] Number of genes p value Function
Integrin-2 pathway [PID] 26 4.17 × 10–6 Cell adhesion
Negative regulation of TCF-dependent signaling by WNT ligand antagonists [Reactome] 15 2.24 × 10–5 Immune response; signal transduction
FCGR activation [Reactome] 11 7.14 × 10–5 Immune response
Keratinization [Reactome] 171 1.94 × 10–4 Cell adhesion
Adipogenesis [WikiPathways] 119 2.23 × 10–4 Lipid metabolism
Photodynamic therapy-induced unfolded protein response [WikiPathways] 26 5.94 × 10–4 Cellular stress response
SNARE interactions in vesicular transport [KEGG] 35 8.63 × 10–4 Neurotransmitter release
Formation of the cornified envelope [Reactome] 118 8.98 × 10–4 Keratinocyte cell barrier
Interferon gamma pathway [ST] 10 0.001 Immune response
  1. *Bold text indicates FDR-corrected p < 0.05