Table 4 Top HMAGMA gene-based associations in the GWAS of resilience to amyloidosis
Gene [Chromosome] | Number of SNPs | p value | Function |
|---|---|---|---|
CNOT7 [8] | 15 | 1.65 × 10–7 | Immune response |
C11ORF97 [11] | 4 | 2.59 × 10–6 | Unknown |
VPS37A [8] | 11 | 3.31 × 10–6 | Endosomal sorting/trafficking |
ZDHHC2 [8] | 40 | 8.20 × 10–6 | Cell adhesion; synaptic plasticity |
RCC1L [7] | 20 | 2.47 × 10–5 | Guanine nucleotide exchange factor |
LINC02449 [12] | 35 | 6.34 × 10–5 | Unknown |
MYOCOS [1] | 29 | 7.23 × 10–5 | Unknown |
RAD24 [8] | 6 | 7.45 × 10–5 | DNA repair/checkpoint pathways |
LINC00987 [12] | 11 | 8.53 × 10–5 | Unknown |
VSTM5 [11] | 82 | 8.64 × 10–5 | Cell adhesion; neuronal morphology |