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Table 4 Top HMAGMA gene-based associations in the GWAS of resilience to amyloidosis

From: Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

Gene [Chromosome] Number of SNPs p value Function
CNOT7 [8] 15 1.65 × 10–7 Immune response
C11ORF97 [11] 4 2.59 × 10–6 Unknown
VPS37A [8] 11 3.31 × 10–6 Endosomal sorting/trafficking
ZDHHC2 [8] 40 8.20 × 10–6 Cell adhesion; synaptic plasticity
RCC1L [7] 20 2.47 × 10–5 Guanine nucleotide exchange factor
LINC02449 [12] 35 6.34 × 10–5 Unknown
MYOCOS [1] 29 7.23 × 10–5 Unknown
RAD24 [8] 6 7.45 × 10–5 DNA repair/checkpoint pathways
LINC00987 [12] 11 8.53 × 10–5 Unknown
VSTM5 [11] 82 8.64 × 10–5 Cell adhesion; neuronal morphology
  1. *Bold text indicates gene-based genome-wide significant association (p < 9.85 × 10–7)