Table 3 Associations of the top GWAS Hit with neuroimaging biomarkers in the MCSA

Global amyloid PET

p = 0.03

N = 546

β = − 0.09

AD-signature tau PET

p = 0.12

N = 106

β = − 0.15

Entorhinal cortex tau PET

p = 0.09

N = 106

β = − 0.17

White matter hyperintensities

p = 0.11

N = 369

β = − 0.07

Corpus callosum genu fractional anisotropy

p = 0.83

N = 420

β = 0.01

Hippocampal volume

p = 0.02

N = 529

β = 0.08

AD-signature cortical thickness

p = 0.01

N = 531

β = 0.10