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Table 3 Associations of the top GWAS Hit with neuroimaging biomarkers in the MCSA

From: Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

Biomarker Chr 8 rs12056505
Global amyloid PET p = 0.03
N = 546 β = − 0.09
AD-signature tau PET p = 0.12
N = 106 β = − 0.15
Entorhinal cortex tau PET p = 0.09
N = 106 β = − 0.17
White matter hyperintensities p = 0.11
N = 369 β = − 0.07
Corpus callosum genu fractional anisotropy p = 0.83
N = 420 β = 0.01
Hippocampal volume p = 0.02
N = 529 β = 0.08
AD-signature cortical thickness p = 0.01
N = 531 β = 0.10