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Table 1 Sample characteristics

From: Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology

  MCSA (Discovery) MCSA (Comparison) ADNI (Replication)
N = 546 N = 953 N = 545
Amyloid positive Amyloid negative Amyloid positive
Age (years) 77.0 (7.7) 70.0 (9.7) 76.1 (7.5)
Sex 255 (47%) women 430 (45%) women 260 (48%) women
291 (53%) men 523 (55%) men 285 (52%) men
Education (years) 14.6 (2.8) 14.9 (2.5) 15.9 (2.8)
Median visit number 4 (1.9) 5 (1.8) 4 (1.9)
APOE ɛ4 status 317 (58%) negative 756 (79%) negative 193 (35%) negative
229 (42%) positive 197 (21%) positive 352 (65%) positive
Diagnosisa 458 (85%) CU 887 (93%) CU 103 (19%) CU
78 (14%) MCI 62 (7%) MCI 223 (41%) MCI
6 (1%) Dementia 1 (0%) Dementia 214 (40%) Dementia
  1. Values displayed as mean (standard deviation) or number (percentage)
  2. CU cognitively unimpaired, MCI mild cognitive impairment
  3. aConsensus clinical diagnosis at the first PET/clinical visit; data unavailable for 4 individuals in the MCSA Discovery, 3 individuals in the MCSA Comparison, and 5 individuals in the ADNI replication samples