Table 2 The statistically significant (and close to significant) differences observed between the drug combinations in their effect on molecular markers

nNOS

–

Yes; F(1,12) = 7.6, p = .0174, \(\omega_{{}}^{2}\) = .23

Saline: mean = 1, SD = .11 / NI: mean = .97, SD = .13; d = .21, p = .78

Flxc: mean = .75, SD = .24 / Flxc + NI: mean = 1.32, SD = .34; d = 1.96, p = .004

–

–

*Flxc + NI significantly different from Flxc (p = .02)

ERK1

–

–

–

–

–

Close; F(1,12) = 4.3, p = .0602, \(\omega_{{}}^{2}\) = .2

–

pERK1

–

–

–

–

–

–

–

pERK1/ERK1

Close, p = .123, d = 1.41

Yes; F(1,12) = 12.48, p = .0041, \(\omega_{{}}^{2}\) = .42

Saline: mean = 1, SD = .36 / NI: mean = .98, SD = .17; d = .06, p = .94

Flxc: mean = .85, SD = .1 / Flxc + NI: mean = 1.6, SD = .18; d = 5.1, p = .0004

–

–

*Flxc + NI significantly different from Saline (p = .013), NI (p = .011), and Flxc (p = .002)

ERK2

Yes; p = .043, d = 2.01

–

–

–

Yes; F(1,12) = 13.83, p = .0029, \(\omega_{{}}^{2}\) = .42

–

Flxc + NI significantly different from NI (p = .02) and Saline (p = .02)

pERK2

Yes; p = .017, d = 2.63

–

–

–

Close; F(1,12) = 4.65, p = .052, \(\omega_{{}}^{2}\) = .14

Yes; F(1,12) = 6.93, p = .0219, \(\omega_{{}}^{2}\) = .23

Flxc + NI significantly different from Saline (p = 0.03)

pERK2/ERK2

–

–

–

–

–

–

–

ERK1/2

–

–

–

–

Close; F(1,12) = 4.28, p = .0608, \(\omega_{{}}^{2}\) = .17

–

–

pERK1/2/ERK1/2

–

Yes; F(1,12) = 8.77, p = .0119, \(\omega_{{}}^{2}\) = .2

Saline: mean = 1, SD = .1 / NI: mean = 1.06, SD = .17; d = .48, p = .7

Flxc: mean = .9, SD = .38 / Flxc + NI: mean = 1.61, SD = .1; d = 2.51, p = .0006

–

–

*Flxc + NI significantly different from Saline (p = .011), NI (p = .023), and Flxc (p = .004)

ELK1

–

–

–

–

–

Yes; F(1,12) = 8.2, p = .0143, \(\omega_{{}}^{2}\) = .3

Difference between Flxc and NI close to significant (p = .05)

pELK1

Yes; p = .028, d = 2.03

Yes; F(1,12) = 10.87, p = .0006, \(\omega_{{}}^{2}\) = .15

Saline: mean = 1, SD = .45 / NI: mean = 1.34, SD = .62; d = .62, p = .27

Flxc: mean = 1.19, SD = .19 / Flxc + NI: mean = 2.88, SD = .24; d = 7.92, p < .0001

–

–

*Flxc + NI significantly different from Saline (p < .001), NI (p = .001), and Flxc (p < .001)

pELK1/ELK1

Close; p = .095, d = 1.40

Yes; F(1,12) = 6.55, p = .025, \(\omega_{{}}^{2}\) = .11

Saline: mean = 1, SD = .4 / NI: mean = .97, SD = .48; d = .83, p = .11

Flxc: mean = 1.05, SD = .49 / Flxc + NI: mean = 2.55, SD = .13; d = 4.22, p = .0024

–

–

*Flxc + NI significantly different from Saline (p < .001), NI (p < .001), and Flxc (p = .01)

CREB

–

Yes; F(1,12) = 5.36, p = .0392, \(\omega_{{}}^{2}\) = .09

Saline: mean = 1, SD = .37 / NI: mean = 1.22, SD = .17; d = .87, p = .45

Flxc: mean = 1.22, SD = .49 / Flxc + NI: mean = 2.35, SD = .48; d = 2.31, p = .0016

–

–

*Flxc + NI significantly different from Saline (p = .002), NI (p = .009), and Flxc (p = .01)

pCREB

Yes; p = .012, d = 2.91

Yes; F(1,12) = 5.81, p = .0328, \(\omega_{{}}^{2}\) = .12

Saline: mean = 1, SD = .25 / NI: mean = 1.12, SD = .25; d = .87, p = .508

Flxc: mean = 1.07, SD = .26 / Flxc + NI: mean = 1.92, SD = .38; d = 2.31, p = .0015

–

–

*Flxc + NI significantly different from Saline (p = .005), NI (p = .016), and Flxc (p = .009)

pCREB/CREB

–

–

–

–

–

–

–

BDNF

–

Yes; F(1,12) = 13.15, p = .0035, \(\omega_{{}}^{2}\) = .14

Saline: mean = 1, SD = .6 / NI: mean = 1.35, SD = .57; d = .55, p = .809

Flxc: mean = .92, SD = .46 / Flxc + NI: mean = 2.47, SD = .27; d = 4.06, p = .0002

–

–

*Flxc + NI significantly different from Saline (p = .008), NI (p = .013), and Flxc (p = .001)

cFOS

–

Yes; F(1,12) = 37.04, p < .0001, \(\omega_{{}}^{2}\) = .3

Saline: mean = 1, SD = 0 / NI: mean = .95, SD = .17; d = .87, p = .69

Flxc: mean = 1.02, SD = .22 / Flxc + NI: mean = 1.97, SD = .15; d = 2.31, p < .0001

–

–

*Flxc + NI significantly different from Saline (p < .001), NI (p < .001), and Flxc (p < .001)