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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Chronically altered NMDAR signaling in epilepsy mediates comorbid depression

Fig. 2

Assessing the therapeutic efficacy of the treatment combinations based on their effects on change scores of depressive symptoms between the FSTs. Change scores are calculated for each animal by applying the following formula to the relevant values: (FST2–FST1)/FST1. a & d Establishing the baseline change of depressive symptoms between FST1 and FST2 without administration of any treatments. b & e The chronic treatment setting: comparing the effects of Flxc, NI, and their combination on immobility (b) and latency (e) times. c & f The acute treatment setting: comparing the effects of Flxa, NI, and their combination on immobility (c) and latency (f) times. a & d Change scores were compared using the Welch’s t-test and no statistically significant differences were found. b–c & e–f While change scores are shown in the plots for easier interpretation, the data was actually analyzed using two-way ANCOVA using values from FST1 as the covariate. Details of this analysis are presented in the main text

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