Fig. 2

CTE-like neuronal pathology in frontal cortex (middle frontal gyrus) of Case #1. (a) Low magnification of H&E-stained section shows the location (white box) of the CTE-like perivascular cluster of phosph-tau (p-tau) illustrated in adjacent PHF1 + stained section (b). A single cluster of PHF-1 + staining seen in the depth of the cortical sulci (B, black arrow). (c) At a higher magnification the large vessel (black arrow) is surrounded by p-tau + neuronal and astrocyte staining