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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Perspective of mesenchymal transformation in glioblastoma

Fig. 1

The impact of microenvironmental factors on shaping GBM transcriptome. Mesenchymal transition may be induced by a variety of microenvironmental factors such as a interaction between GBM cells and tumor-associated macrophages/microglia b proinflammatory processes induced by radiation c hypoxia and d astrocytes. As depicted in the figure, GBM is a highly heterogeneous tumor consisting of several cellular entities, such as fibroblasts, immune cells, and astrocytes and also of GBM cells harboring different transcriptomic signatures. For the representation of GBM cells with the distinctive transcriptomic states, only mesenchymal and proneural cells are portrayed

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