Fig. 3

Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD neurons in postmortem patient motor cortex. a Immunostaining for Lamin B1 in postmortem paraffin embedded motor cortex sections. Genotype as indicated on left, antibody as indicated on top. b Quantification of nuclear circularity. n = 8 control and 8 C9orf72 cases, at least 100 Map2 + neurons per case. Student’s t-test was used to calculate statistical significance. c Quantification of number of Lamin B1 invaginations per nucleus. n = 8 control and 8 C9orf72 cases, at least 100 Map2 + neurons per case. Chi-square test was used to calculate statistical significance. Scale bar = 10 μm