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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Early alterations of neurovascular unit in the retina in mouse models of tauopathy

Fig. 5

Characterization of retinal pathogenesis in P301L mice at 3 months of age. a Total tau (green) was stained with tau antibody in retinal sections from 3-month-old WT and P301L mice. n = 4/group. b OCT analysis of retinal thickness. n = 20–26/group. c Retinal permeability. n = 8/group. d Leukostasis. Bar graph represents the number of stationary leukocytes adherent to the retinal vasculature per retina. n = 14–18/group. e Microglia were stained with anti-Iba1 antibody (purple) and images were taken at the NFL-GCL by confocal microscopy. Squares in the upper panel of images are zoomed in to show microglial activation. Bar graph represents the number of microglia at the NFL-GCL. n = 7–8/group. f Representative images of retinal flatmounts labeled with Tuj1 antibody (green) for RGCs and Opsin 4 antibody (purple) for ipRGCs at the peripheral retina. Arrowheads indicate the soma of ipRGCs. Bar graphs represent the numbers of RGCs and ipRGCs per field. n = 10–11/group; eight images were taken at the peripheral retina for each sample and calculated as average value. g ERG analysis (pSTR) over a range of stimulus strengths. n = 6/group. Scale bar: 50 µm. *p < 0.05; **p < 0.01; ****p < 0.0001 versus WT

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