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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Fig. 8

Dlp is altered in the context of TDP-43 proteinopathy. Dlp mRNA is enriched in TDP-43 complexes, depleted from ribosomes and sequestered in insoluble/urea complexes. Taken together, these findings and our observations of Dlp protein being reduced at the NMJ and accumulating in puncta within cell bodies and neuropils suggest multiple cellular defects including local translation inhibition at synapses, axonal trafficking and endomembrane trafficking deficits

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