Fig. 5

Dlp protein expression is altered by TDP-43 proteinopathy. a–l Representative images of w¹¹¹⁸, TDP-43^WT, TDP-43^G298S and TBPH^RNAi NMJs stained for Dlp and HRP. m Quantification of Dlp protein relative to bouton area in terminal boutons. N = 13 for w¹¹¹⁸, 15 for TDP-43^WT, 16 for TDP-43^G298S, 6 for TBPH^RNAi. n–y Representative images of w¹¹¹⁸, TDP-43^WT, TDP-43^G298S and TBPH^RNAi VNCs stained for Dlp, DNA and TDP-43 (z). Quantification of Dlp granule number in the neuropil. N = 10 for w¹¹¹⁸, 10 for TDP-43^WT, 9 for TDP-43^G298S, 6 for TBPH^RNAi. Genotypes and stainings, as indicated. Scale bars: a 10 μm, n 50 μm. v 22 μm. Significance determined using the Holm Sidak’s multiple comparison test. *P_value < 0.05, **P_value < 0.01, ***P_value < 0.001. Error bars represent SEM