Fig. 3

Direct Targets of TDP-43 Mediated Translation Regulation. a Overlap between genes enriched with TDP-43 (log2FC > 1, P_adj < 0.05) and depleted with RpL10 (log2FC < −1) relative to the w¹¹¹⁸ control. b, c GO terms for TDP-43 enriched, RpL10 depleted genes.in TDP-43^WT (b) or TDP-43^G298S (c) models. d, e RpL10 depletion (TRAP) and TDP-43 enrichment (RIP) for genes constituting significant GO terms in TDP-43^WT (d) and TDP-43^G298S (e). f Overlap between genes enriched with TDP-43 (log2FC > 1, P_adj < 0.05) and enriched with RpL10 (log2FC > 1) relative to the w¹¹¹⁸ control. g, h GO terms for TDP-43 enriched, RpL10 enriched genes.in TDP-43^WT (g) or TDP-43^G298S (h) models. i, j RpL10 enrichment (TRAP) and TDP-43 enrichment (RIP) for genes constituting significant GO terms in TDP-43^WT (i) and TDP-43^G298S (j). d–e, i–j Closest human orthologs identified using DIOPT are denoted in parentheses to the right of the fly gene names