Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Fig. 2

Translational Alterations Induced by TDP-43 Proteinopathy. a Experimental schematic for RNA immunoprecipitations of human TDP-43, specifically from the motor neurons of third instar larvae. b STRING clusters from genes in the top 10% of normalized counts associated with RpL10-GFP in w1118 larvae (control motor neuron translatomes). c Altered ribosome association of spliceosome genes in TDP-43WT relative to the control. d Altered ribosome association of purine metabolism genes in TDP-43G298S relative to control. e Altered ribosome association of oxidative phosphorylation genes in TDP-43G298S relative to control. f Altered ribosome association of translation associated genes in TDP-43G298S relative to control. g, h GO terms for RpL10 depleted genes (log2FC < −1) (g) and RpL10 enriched genes (log2FC > 1) (h) shared between both TDP-43WT and TDP-43G298S models

Back to article page