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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Fig. 1

mRNAs Enriched with TDP-43 in A Drosophila Model of ALS. a Experimental schematic for RNA immunoprecipitations of human TDP-43, specifically from the motor neurons of third instar larvae. b, c Volcano plot displaying mRNAs enriched with TDP-43 in TDP-43WT (b) and TDP-43G298S. All genes associated with TDP-43 (log2FC > 0) are displayed regardless of significance. c) proteinopathy, relative to transcript levels in the ventral nerve cord. d–g GO terms for TDP-43 enriched genes (log2FC > 2, Padj < 0.05) either unique to TDP-43WT (e) or TDP-43G298S (f) or shared between genotypes (g)

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