Fig. 6From: Tau antibody isotype induces differential effects following passive immunisation of tau transgenic miceRN2N IgG1 reduces microgliosis following passive immunization. Iba1 labelling of cortical brain sections of WT and pR5 mice in three treatment groups. PBS and IgG2a treated pR5 mice demonstrate a significant increase in the Iba1-positive percentage area, cell count and average cell size compared to WT mice. Treatment of pR5 mice with IgG1 restores Iba1-positive percentage area, cell count, and average cell size to WT levels (WT: n = 9; PBS: n = 10: IgG1: n = 9; IgG2a: n = 10). **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. Scale bar: 100 μmBack to article page