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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice

Fig. 6

RN2N IgG1 reduces microgliosis following passive immunization. Iba1 labelling of cortical brain sections of WT and pR5 mice in three treatment groups. PBS and IgG2a treated pR5 mice demonstrate a significant increase in the Iba1-positive percentage area, cell count and average cell size compared to WT mice. Treatment of pR5 mice with IgG1 restores Iba1-positive percentage area, cell count, and average cell size to WT levels (WT: n = 9; PBS: n = 10: IgG1: n = 9; IgG2a: n = 10). **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. Scale bar: 100 μm

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