Fig. 5

RN2N IgG1 treatment reduces AT180-positive tau inclusions in the amygdala of pR5 mice. a Representative images of AT8 immunoreactivity observed in the amygdala of pR5 mice in each treatment group and quantification of % area positivity of AT8-positive cells in the amygdala (PBS: n = 9; IgG: n = 10; IgG2a: n = 10). b Representative images of AT180 immunoreactivity observed in the amygdala of pR5 mice in each treatment group and quantification of % area positivity of AT180-positive cells in the amygdala (PBS: n = 10; IgG1: n = 9; IgG2a: n = 10). There was a significant reduction in % area positivity of AT180 in the amygdala in mice treated with IgG1 compared to mice treated with PBS. *p ≤ 0.05. Scale bars: left panel, 200 μm; right panel, 50 μm