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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca2+ alteration and multiphasic transmitter release

Fig. 7

Contribution of anion channels to Ca2+-dependent glutamate release. a Aβ-evoked astrocytic Ca2+ rises were due to purinergic receptor activation. To examine Ca2+-dependent glutamtae release, we applied ATP (30 µM) to trigger astrocytic Ca2+ and glutamate release. bd Ca2+-dependent glutamate release was unaffected by inhibition of CX hemichannel (CBX, 100 µM), but reduced by blocking anion channels with NPPB (100 µM) (n = 7–9 cells per condition). e During the response to Aβ25–35 (6 µM), inhibiting anion channels with DCPIB (50 µM) influenced the glutamate release during Ca2+ elevation phase (n = 10–12 cells per condition)

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