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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Prolonged activation of cytomegalovirus early gene e1-promoter exclusively in neurons during infection of the developing cerebrum

Fig. 9

Immunohistochemical detection of MCMV-IE3, -E1, -M45 and EGFP in the serial sections of the HP infected with rMCMV1373 (ad) or -448 (eh) at 11 dpi. a, e MCMV-IE3 (brown) is expressed in the nuclei of the hippocampal neurons infected with either rMCMV1373 (a) or rMCMV448 (e). b, f MCMV-E1 (brown) is expressed in the nuclei in a similar manner to IE3. c, g MCMV-M45 (brown) is also expressed in the cytoplasm of hippocampal neurons with a pyramidal morphology. d, h EGFP (brown) was strongly expressed in the whole cell bodies of pyramidal neurons in the rMCMV1373-infected HP (d), but not expressed in the rMCMV448-infected HP (h). Nuclei are counterstained with hematoxylin. LV, lateral ventricle. Scale bars: ah 100 µm

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