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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Fig. 7

Mitochondrial ATP-production is significantly recovered in retinas from Tg2576 AD mice following passive immunization with 12A12mAb. Analyses of mitochondrial functionality (n = 8) carried out on homogenates from retina specimens are shown. a Citrate synthase (CS) and cytochrome oxidase (COX) specific activities measurements. b MRC complex activities: the activities of complex I (NADH:ubiquinone oxidoreductase), complex II (succinate:ubiquinone oxidoreductase), complex III (cytochrome c reductase), complex IV (cytochrome c oxidase) and complex V (ATP synthase). A schematic representation of OXPHOS system is also reported in the inset. c The cellular ATP content. Statistically significant differences were calculated by one-way analysis of variance (ANOVA) followed by Bonferroni’s post-hoc test for multiple comparison among more than two groups. p < 0.05 was accepted as statistically significant (*p < 0.05; **p < 0.01; ***p < 0.0005; ****p < 0.0001)

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