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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis

Fig. 5

Impact of TBI and antibiotic induced gut microbial dysbiosis on neurogenesis. a Representative images of NeuN + cells in the ipsilateral hippocampi. Mean values are plotted ± SEM, two-way ANOVA followed by Tukey's multiple comparisons. F statistic for antibiotic*injury presented unless otherwise noted (*p < 0.05, **p < 0.01 ***p < 0.001, ****p < 0.0001). b Stereological quantification, Finjury (1,19) = 80.2, p < 0.0001. c Experimental design. d Representative fluoroscopy of the SGZ in the DG of the hippocampus labeled with BrdU (magenta), NeuN (red), and DCX (green) (1cell expressing BrdU/DCX/NeuN, 2cell expressing BrdU/DCX and and 3cell expressing BrdU only). e Quantification of stained cells per area per condition. f Summation of total neuronal lineage cells per area of hippocampi, F(1,14) = 20.8, p < 0.0005. Abbreviations: VNAM, vancomycin, neomycin-sulfate, ampicillin and metronidazole; CCI, controlled cortical impact; SGZ, subgranular zone; DG, dentate gyrus; DCX, doublecortin; BrdU, 5-Bromo-2´-Deoxyuridine

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