Fig. 7

Accumulation of human α-syn within the liver promotes inflammation in the A30P mouse model of PD. A–D Confocal image analysis on aged A30P liver sections demonstrate the presence of CD45-positve leukocytes, E–H CD11b-positive monocytes and I–L F4/80-positive Kupffer cells next to or in close proximity to α-syn deposits. M–P Partial co-localization between α-syn and the GFAP-positive perisinusoidal cells within the sinusoidal region. All tissue sections were counterstained with DAPI (blue). Bars = 20 µm