Fig. 5

Alpha-synuclein is transported from the brain to the liver following a single striatal injection of mouse α-syn (mα-syn) oligomers. B–D, F–H mα-syn oligomers are detected within the portal tracts of the wild type mice 1-month post striatal injection. A, E Adjacent tissue sections lacking primary antibody (1°delete) show no mα-syn immunoreactivity. I–L Injected mα-syn oligomers detected within the portal tracts or M–P liver parenchyma are not phosphorylated at serine 129 (pS129) 1-month post injection. All tissue sections were counterstained with DAPI (blue). Bars = 20 µm