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Table 2 Histopathological and PrP immunohistochemical (IHC) features of inoculated Tg mice (1st passage)

From: Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt–Jakob disease with codon 129VV genotype faithfully propagate in vivo

Mouse line Inoculum H.E PrP IHC pattern
SD topography Vacuole size Plaques Cerebral Cortex (CC) Cerebellum
Tg129V VV120 ↑CC- ↓Tha Medium No Granul. Aggreg Focal, Grl. L
VV121−20* ↑CC- ↓Th Medium No Granul. Aggreg Focal, Grl. L
VV121 ↑CC- ↓Th Medium No Granul. Aggreg Negative
Tg129M VV120 ↑CC- ↓Th Large No Granul. Aggreg Focal, Grl. L
VV121−20* ↑CC- ↓Th Large No Negative Negative
VV121 Negative
Tg129V VV2 ↓CC- ↑Th Small Yes, BS Plaque-like Negative
Tg129M VV2 ↓CC- ↑Th Small Yes, widespread Plaques Plaques & plaque-like
  1. aArrows depict gradients of lesion severity: upward arrow = maximum; downward arrow = minimum; H.E.: Hematoxylin–eosin; SD: spongiform degeneration; CC: cerebral cortex; Th: thalamus; Granul. Aggreg.: granule aggregate; Grl. L.: granule cell layer; BS: brainstem