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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Neuronal hibernation following hippocampal demyelination

Fig. 5

Demyelination increases astrocyte participation in the tripartite synapse. a EM image showing presynaptic terminal (blue), dendritic spine (green), and astrocyte process apposing synaptic cleft (tan). b Reconstruction of the relationship between the astrocyte and the synaptic terminal. c Compared to myelinated hippocampi, the percentage of synapses with astrocytes at the synaptic cleft is significantly increased in demyelinated and remyelinated hippocampi. d Correlation between spine head volume (green lines) and astrocyte participation (tan lines) in the tripartite synapse. Compared to myelinated hippocampi, demyelinated and remyelinated hippocampi have increased astrocyte participation in the tripartite synapse that is independent of spine head volume. Demyelination increased the percent increase in astrocyte contact. e RNA-seq analysis identified alterations in 29 astrocyte-specific transcripts in demyelinated hippocampus. Of note are increases in transcripts that encode astrocyte proteins that reduce extracellular glutamate (Slc7a11) and suppress CA1 neuronal activity (Slc1A3)

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