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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Neuronal hibernation following hippocampal demyelination

Fig. 4

Post-synaptic density (PSD) area is increased and appears more mature in demyelinated hippocampi. We reconstructed the size (area) and shape of PSDs in serial 3D EM reconstructions. a Three EM images of spine head showing PSD beneath post-synaptic membrane. b Reconstruction of this macular-shaped spine showing orientation of the images in panel a (a1-a3). c Three serial EM images of spine head showing PSD beneath post-synaptic membrane. d Reconstruction of this perforated-shaped spine showing orientation of the images in panel c (c1-c3). e Compared to myelinated hippocampi, PSD area/spine is significantly increased in demyelinated and remyelinated hippocampi. f After correcting for the increase in total spine area, PSD area was still increased in demyelinated and remyelinated hippocampi. g The percentage of perforated PSDs was significantly increased in demyelinated and remyelinated hippocampi

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