Fig. 5

Regional distribution of WM and adjacent GM pathology burden in clinicopathological groups. Plots portray the regional distribution of WM and GM pathology burden in clinicopathological groups, i.e. a PPA with FTLD-Tau (nonfluent/agrammatic variant, naPPA) and PPA with FTLD-TDP (semantic variant, svPPA), and b bvFTD with FTLD-Tau and bvFTD with FTLD-TDP. The color scale represents least-square means of ln-transformed WM and GM %AO in each region derived from linear-mixed effects (LME) models adjusting for demographics. Asterisks denote areas of peak pathology burden. Legend: %AO = percentage area occupied by pathology; ACG = anterior cingulate gyrus; ANG = angular gyrus; bvFTD = behavioral variant of frontotemporal dementia; FTLD-Tau = frontotemporal lobar degeneration with inclusions of the tau protein; FTLD-TDP = frontotemporal lobar degeneration with inclusions of the TDP-43 protein; GM = grey matter; MFC = middle frontal cortex; naPPA = nonfluent/agrammatic variant of primary progressive aphasia; OFC = orbitofrontal cortex; STG = superior temporal gyrus; svPPA; semantic variant of primary progressive aphasia; WM = white matter