Fig. 1

WM and GM pathology burden in FTLD-Tau and FTLD-TDP subtypes. Raw pathology photomicrographs and red digital overlay of %AO detection in middle frontal cortex of each proteinopathy subtype: all FTLD-Tau subtypes display abundant white matter pathology in glia and axonal threads, whereas in FTLD-TDP subtypes white matter pathology are less prominent and largely restricted to oligodendrocytes. Scale bar = 100 µm. Legend: %AO = percentage area occupied by pathology; CBD = corticobasal degeneration; FTLD-Tau = frontotemporal lobar degeneration with inclusions of the tau protein; FTLD-TDP = frontotemporal lobar degeneration with inclusions of the TDP-43 protein; GM = grey matter; MAPT = tau with MAPT gene mutation; PiD = Pick’s disease; PSP = progressive supranuclear palsy; Type A/Type B/Type C/Type E = subtypes of FTLD-TDP pathology; WM = white matter