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Table 4 Correlations between p-tau Thr181 levels and behavioral parameters in the elevated zero maze

From: Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

Elevated zero maze

p-tau (Thr181)

Pearson

Kendall's tau-b

Spearman's rho

Correlation coefficient

p value

Correlation coefficient

p value

Correlation coefficient

p value

Left anterior cortex

Move distance

 − .792

.006

 − .600

.016

 − .806

.005

Open arm time

 − .620

.056

 − .422

.089

 − .576

.082

Cross arm latency

.624

.054

.556

.025

.782

.008

Right anterior cortex

Move distance

 − .814

.004

 − .600

.016

 − .806

.005

Open arm time

 − .676

.032

 − .511

.040

 − .624

.054

Cross arm latency

.493

.148

.467

.060

.721

.019

Left Hippocampus

Move distance

.010

.979

 − .156

.531

 − .055

.881

Open arm time

 − .173

.633

 − .156

.531

 − .115

.751

Cross arm latency

 − .033

.928

.022

.929

.042

.907

Right Hippocampus

Move distance

 − .901

 < .001

 − .733

.003

 − .891

.001

Open arm time

 − .755

.008

 − .644

.009

 − .842

.002

Cross arm latency

.564

.090

.689

.006

.879

.001

Left Amygdala

Move distance

.120

.741

.156

.531

.248

.489

Open arm time

.118

.745

 − .022

.929

.042

.907

Cross arm latency

.415

.233

 − .111

.655

 − .103

.777

Right Amygdala

Move distance

 − .016

.966

.111

.655

.127

.726

Open arm time

.198

.584

.289

.245

.382

.276

Cross arm latency

 − .293

.412

 − .244

.325

 − .285

.425

Left Posterior Cortex

Move distance

 − .074

.839

.067

.788

.103

.777

Open arm time

.057

.877

.156

.531

.055

.881

Cross arm latency

.499

.142

.244

.325

.345

.328

Right Posterior Cortex

Move distance

.199

.581

.111

.655

.224

.533

Open arm time

.479

.161

.200

.421

.345

.328

Cross arm latency

 − .105

.772

 − .067

.788

 − .091

.803

  1. P-tau Thr181 levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21] and correlated with three behavioral measures in the elevated zero maze (move distance, open arm time and cross arm latency) previously found to be affected in the same blast-exposed rats at 30 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold
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Acta Neuropathologica Communications

ISSN: 2051-5960

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