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Table 4 Correlations between p-tau Thr181 levels and behavioral parameters in the elevated zero maze

From: Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

Elevated zero maze
p-tau (Thr181) Pearson Kendall's tau-b Spearman's rho
Correlation coefficient p value Correlation coefficient p value Correlation coefficient p value
Left anterior cortex
Move distance  − .792 .006  − .600 .016  − .806 .005
Open arm time  − .620 .056  − .422 .089  − .576 .082
Cross arm latency .624 .054 .556 .025 .782 .008
Right anterior cortex
Move distance  − .814 .004  − .600 .016  − .806 .005
Open arm time  − .676 .032  − .511 .040  − .624 .054
Cross arm latency .493 .148 .467 .060 .721 .019
Left Hippocampus
Move distance .010 .979  − .156 .531  − .055 .881
Open arm time  − .173 .633  − .156 .531  − .115 .751
Cross arm latency  − .033 .928 .022 .929 .042 .907
Right Hippocampus
Move distance  − .901  < .001  − .733 .003  − .891 .001
Open arm time  − .755 .008  − .644 .009  − .842 .002
Cross arm latency .564 .090 .689 .006 .879 .001
Left Amygdala
Move distance .120 .741 .156 .531 .248 .489
Open arm time .118 .745  − .022 .929 .042 .907
Cross arm latency .415 .233  − .111 .655  − .103 .777
Right Amygdala
Move distance  − .016 .966 .111 .655 .127 .726
Open arm time .198 .584 .289 .245 .382 .276
Cross arm latency  − .293 .412  − .244 .325  − .285 .425
Left Posterior Cortex
Move distance  − .074 .839 .067 .788 .103 .777
Open arm time .057 .877 .156 .531 .055 .881
Cross arm latency .499 .142 .244 .325 .345 .328
Right Posterior Cortex
Move distance .199 .581 .111 .655 .224 .533
Open arm time .479 .161 .200 .421 .345 .328
Cross arm latency  − .105 .772  − .067 .788  − .091 .803
  1. P-tau Thr181 levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21] and correlated with three behavioral measures in the elevated zero maze (move distance, open arm time and cross arm latency) previously found to be affected in the same blast-exposed rats at 30 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold