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Table 13 Correlations between p-tau Thr181 levels and parameters in acoustic startle and prepulse inhibition

From: Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

Acoustic startle/prepulse inhibition
p-tau (Thr181) Pearson Kendall's tau-b Spearman's rho
Correlation coefficient p value Correlation coefficient p value Correlation coefficient p value
Left anterior cortex
Pulse-prepulse  − .245 .496  − .111 .655  − .067 .855
PPI (%) .317 .371 .289 .245 .467 .174
Right anterior cortex
Pulse-prepulse  − .221 .539  − .111 .655  − .042 .907
PPI (%) .314 .376 .289 .245 .358 .310
Left Hippocampus
Pulse-prepulse  − .520 .123  − .378 .128  − .503 .138
PPI (%)  − .047 .898  − .244 .325  − .333 .347
Right Hippocampus
Pulse-prepulse  − .179 .620  − .156 .531  − .224 .533
PPI (%) .430 .215 .244 .215 .418 .229
Left Amygdala
Pulse-prepulse .506 .136 .289 .245 .479 .162
PPI (%) .146 .688 .244 .325 .164 .651
Right Amygdala
Pulse-prepulse  − .240 .505  − .022 .929  − .127 .726
PPI (%)  − .105 .774  − .067 .788  − .091 .803
Left Posterior Cortex
Pulse-prepulse  − .080 .825  − .067 .788  − .067 .855
PPI (%)  − .247 .492  − .022 .929  − .018 .960
Right Posterior Cortex
Pulse-prepulse .155 .669 .067 .788 .067 .855
PPI (%) .151 .677 .111 .655 .127 .726
  1. P-tau Thr181 levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21] and correlated with measures previously found to be affected in the same blast-exposed rats at 34 weeks following blast exposure [80]. Pulse refers to the first startle reading. Pulse-prepulse refers to background readings (prepulse) subtracted from the startle (pulse). Percent prepulse inhibition (PPI) was calculated with the formula 100 − (startle response on acoustic prepulse plus pulse stimulus trials/pulse stimulus response alone trials) × 100]. Five blast and five control animals were analyzed. There were no statistically significant correlations