Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

Table 12 Correlations between p-tau Thr181 and total tau levels with the discrimination index in a novel object localization task

Novel object localization (discrimination index)
p-tau (Thr181)	Pearson		Kendall's tau-b		Spearman's rho
p-tau (Thr181)	Correlation coefficient	p value	Correlation coefficient	p value	Correlation coefficient	p value
Left anterior cortex	− .791	.006	− .644	.009	− .842	.002
Right anterior cortex	− .781	.008	− .556	.025	− .685	.029
Left Hippocampus	− .299	.402	− .111	.655	− .200	.580
Right Hippocampus	− .732	.016	− .600	.016	− .794	.006
Left Amygdala	.110	.762	− .067	.788	− .030	.934
Right Amygdala	− .377	.283	− .111	.655	− .273	.446
Left Posterior Cortex	.136	.707	.022	.929	.055	.881
Right Posterior Cortex	− .238	.509	− .111	.655	− .127	.726
Total tau vs. discrimination index
Left anterior cortex	.142	.696	− .022	.929	.055	.881
Right anterior cortex	− .367	.296	.200	.421	− .285	.425
Left Hippocampus	.562	.091	.467	.060	.648	.043
Right Hippocampus	.409	.240	.422	.089	.527	.117
Left Amygdala	− .142	.695	− .111	.655	− .111	− .067
Right Amygdala	.462	.179	.378	.128	.515	.128
Left Posterior Cortex	.151	.677	.111	.655	.127	.726
Right Posterior Cortex	− .704	.023	− .467	.060	− .673	.033

P-tau Thr181 levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure. [21]. P-tau levels were correlated with the discrimination index in a novel object localization task previously found to be affected in the same blast-exposed rats at 33 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold

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