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Table 10 Correlations between p-tau Thr181 and total tau levels with freezing in the cued phase of a fear-conditioning paradigm

From: Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

Cued Fear (freezing)

 

Pearson

Kendall's tau-b

Spearman's rho

p-tau (Thr181) vs. freezing

Correlation coefficient

p value

Correlation coefficient

p value

Correlation coefficient

p value

Left anterior cortex

.789

.007

.809

.001

.924

 < 0.001

Right anterior cortex

.692

.031

.539

.031

.736

.015

Left Hippocampus

.296

.406

.270

.281

.304

.393

Right Hippocampus

.593

.071

.405

.106

.565

.089

Left Amygdala

 − .052

.887

.090

.719

.116

.751

Right Amygdala

.323

.363

.315

.209

.438

.206

Left Posterior Cortex

.095

.795

.000

1.000

 − .018

.960

Right Posterior Cortex

 − .211

.553

.045

.857

 − .030

.934

Total tau vs. freezing

Left anterior cortex

.085

.816

.180

.472

.201

.578

Right anterior cortex

.347

.326

.180

.472

.261

.466

Left Hippocampus

 − .376

.284

 − .360

.151

 − .486

.154

Right Hippocampus

 − .484

.157

 − .315

.209

 − .432

.213

Left Amygdala

 − .017

.963

 − .135

.590

 − .243

.498

Right Amygdala

 − .581

.078

 − .584

.020

 − .711

.021

Left Posterior Cortex

 − .243

.500

 − .180

.472

 − .316

.374

Right Posterior Cortex

.393

.262

.360

.151

.523

.121

  1. P-tau Thr181 and total tau levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21]. P-tau levels were correlated with freezing to the second tone in the cued testing phase of a fear learning task previously found to be affected in the same blast-exposed rats at 35 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold
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Acta Neuropathologica Communications

ISSN: 2051-5960

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