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Table 10 Correlations between p-tau Thr181 and total tau levels with freezing in the cued phase of a fear-conditioning paradigm

From: Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

Cued Fear (freezing)
  Pearson Kendall's tau-b Spearman's rho
p-tau (Thr181) vs. freezing Correlation coefficient p value Correlation coefficient p value Correlation coefficient p value
Left anterior cortex .789 .007 .809 .001 .924  < 0.001
Right anterior cortex .692 .031 .539 .031 .736 .015
Left Hippocampus .296 .406 .270 .281 .304 .393
Right Hippocampus .593 .071 .405 .106 .565 .089
Left Amygdala  − .052 .887 .090 .719 .116 .751
Right Amygdala .323 .363 .315 .209 .438 .206
Left Posterior Cortex .095 .795 .000 1.000  − .018 .960
Right Posterior Cortex  − .211 .553 .045 .857  − .030 .934
Total tau vs. freezing
Left anterior cortex .085 .816 .180 .472 .201 .578
Right anterior cortex .347 .326 .180 .472 .261 .466
Left Hippocampus  − .376 .284  − .360 .151  − .486 .154
Right Hippocampus  − .484 .157  − .315 .209  − .432 .213
Left Amygdala  − .017 .963  − .135 .590  − .243 .498
Right Amygdala  − .581 .078  − .584 .020  − .711 .021
Left Posterior Cortex  − .243 .500  − .180 .472  − .316 .374
Right Posterior Cortex .393 .262 .360 .151 .523 .121
  1. P-tau Thr181 and total tau levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21]. P-tau levels were correlated with freezing to the second tone in the cued testing phase of a fear learning task previously found to be affected in the same blast-exposed rats at 35 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold