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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Alzheimer’s disease brain contains tau fractions with differential prion-like activities

Fig. 6

AD tau fractions template tau aggregation in cultured cells distinctively. a, b HeLa cells were transfected with pCI/HA-tau151-391 and treated with AD tau fractions containing similar tau levels. The cells were immunostained with anti-HA, followed by Alex488-Anti-mouse IgG. The numbers of cells with tau aggregation were counted. The data on the percentage of cells with aggregation are presented as mean ± SD. *p < 0.05, ***p < 0.001, ****p < 0.0001. c, d HEK-293FT/HA-tau151-391 cells treated with AD tau fractions containing similar tau levels. The cells were lysed in RIPA buffer 42 h after treatment. RIPA-soluble (c) and -insoluble (d) taus were analyzed by Western blots developed with anti-HA and a mixture of R134d and 92e

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