Fig. 5
From: Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization
Ribosomal protein mRNA are upregulated in SALS spinal motor neurons. a Volcano plot of differential gene expression from laser capture microdissection of SALS spinal motor neurons compared to controls. Significance level, p = 0.05 and p = 0.01 are marked with blue and black lines, respectively. Large (dark purple) and small (light purple) ribosomal protein subunit genes are denoted (pseudogenes are included). b Fold change are shown for the top 5 differentially expressed large or small ribosomal protein subunit mRNAs. c Fold enrichment for significantly enriched gene ontology terms relating to ribosomal biogenesis and protein translation. d Schematic representation of nucleolar stress preceding antisense RNA foci and TDP-43 mislocalization in C9-ALS and SALS spinal motor neurons